Kimberley Akimbo follows a 16 year old girl suffering from a form of Progeria, a disease that causes her to age 4½ times faster than she should. When asked, "What's a couple of days," she jokingly responds, "In Kimberly time, it's about a week and a half. It's like dog years!" In addition to her bodily disease, her life is diseased as well. She lives with her mother, a pregnant hypochondriac, and her alcoholic father. Then her delusional and often homeless aunt moves into their basement and gets Kimberly and one of her school acquaintances, the ever awkward Jeff, mixed up in an illegal money scheme.